Subcutaneous and sublingual immunotherapy

Since the late'90s, there are increasing studies on sublingual immunotherapy (slit), the Allergy certainly know well. Also for the mechanism of the slit is now before the first concept. Sun explained Prof. Dr. Dr. sci it. Thomas Bieber, Bonn that the (successful) application of the sublingual immunotherapy the Langerhans cells in the mouth probably play an important role. These immune cells are not only important in initiating immunity, but also for the tolerance to the environment emanating from the allergens in question. As part of the slit bring these oral Langerhans cells are likely not only (indirectly) the TH2 cells to be propagated TH1, but may activate the neutral equilibrium important T-cells. The oral Langerhans cells of the mouth thus differ according to the research findings of the working group to Bieber markedly fromthe Langerhans cells of the skin. 
Specific Immunotherapy asthma before bowing
The goal is to the specific immunotherapy even easier, safer and more acceptable shut, said Dr. med Vera Mahler, Erlangen. This is achieved by improving the active ingredients, so the allergens achieved. By even better compatibility can be achieved higher doses at shorter intervals to be - an important prerequisite for a short-immunotherapy, such as with the SIT preparation of POLLINEX Quattro Bencard can be carried out. Continue to be important: The right carrier, such as Monophosphoryl-lipid A (MPL). More than 30,000 volunteers aged between one and 84 years have so far been investigated and consistently was a very good TH1 effectiveness in stimulating demonstrated good tolerability. The show also studies with the drug SIT POLLINEX Quattro, with the example Grass pollen allergy with only four injections per year before the pollen were treated. Even the short-term immunotherapy with tree pollen Allergoiden and MPL was after only four injections to be effective and safe.